The pharmacology and mechanism of action of riluzole

摘要: The excitotoxic hypothesis of neurodegeneration has stimulated much interest in the possibility using compounds that will block processes to treat neurologic disorders. Riluzole is a neuroprotective drug blocks glutamatergic neurotransmission CNS. inhibits release glutamic acid from cultured neurons, brain slices, and corticostriatal neurons vivo. It thought these effects may be partly due inactivation voltage-dependent sodium channels on nerve terminals, as well activation G-protein-dependent signal transduction process. also some postsynaptic by noncompetitive blockade N-methyl-D-aspartate (NMDA) receptors. In vivo, riluzole neuroprotective, anticonvulsant, sedative properties. rodent model transient global cerebral ischemia, complete suppression ischemia-evoked surge been observed. vitro, protects anoxic damage, toxic glutamic-acid-uptake inhibitors, factor CSF patients with amyotrophic lateral sclerosis.