Emerging role of ubiquitin-specific protease 14 in oncogenesis and development of tumor: Therapeutic implication.
作者： Bing Liu , Jiangping Chen , Song Zhang
DOI: 10.1016/J.LFS.2019.116875
关键词:
摘要: Ubiquitin (Ub) is a small protein that can be attached to substrate proteins direct their degradation via the proteasome. Deubiquitinating enzymes (DUBs) reverse this process by removing ubiquitin from its protein. Over past few decades, ubiquitin-specific protease 14 (USP14), member of DUBs, has emerged as an important player in various types cancers. In article, we review and summarize biological function USP14 tumorigenesis multiple signaling pathways. To determine role cancer, analyzed gene expression across panel tumors, discussed it could serve novel bio-marker several cancer. And recent contributions indicated been shown act tumor-promoting AKT, NF-κB, MAPK pathways etc. Besides, drugs targeting have potential anti-tumor effect clinical significance. We focus on studies explore link between further discuss target for cancer therapy.
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