Aspirin analgesia evaluated by event-related potentials in man: possible central action in brain.
作者： A.C.N. Chen , C.R. Chapman
DOI: 10.1007/BF00239300
关键词:
摘要: The mechanism of aspirin analgesia is still unclear, but it generally assumed that exerts its analgesic effect mainly on peripheral nociceptors. In this study, we demonstrate possible brain effects 975 mg in man. When electrical potentials evoked by painful tooth shocks were examined, was observed to significantly reduce the amplitude late waveform components, did not affect earlier components. Since our findings suggest early components reflect energy transmission and manifest activities an individual's perception information, postulate may act centrally pain processing.
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J.A. Harvey, L.M. Yunger, RELATIONSHIP BETWEEN TELENCEPHALIC CONTENT OF SEROTONIN AND PAIN SENSITIVITY Serotonin and Behavior. pp. 179- 189 ,(1973) , 10.1016/B978-0-12-078150-8.50029-3
R K Lim, F Guzman, D W Rodgers, R J Engle, G D Dickerson, K Goto, C Braun, SITE OF ACTION OF NARCOTIC AND NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN. Archives internationales de pharmacodynamie et de thérapie. ,vol. 152, pp. 25- 58 ,(1964)
Monte S. Buchsbaum, Glenn C. Davis, Application of Somatosensory Event Related Potentials to Experimental Pain and the Pharmacology of Analgesia Springer, Boston, MA. pp. 43- 54 ,(1979) , 10.1007/978-1-4684-3483-5_4
DONALD SCOTT, THE ANALYSIS AND INTERPRETATION OF PHASIC POTENTIALS FROM THE TOOTH Oral Physiology#R##N#Proceedings of the International Symposium Held in Wenner–Gren Center, Stockholm, August 1971. pp. 263- 280 ,(1972) , 10.1016/B978-0-08-016972-9.50029-X
M.H. Aprison, Advances in biochemical psychopharmacology: Volume 1, edited by E. Costa and P. Greengard, Raven press (1969) Neuropharmacology. ,vol. 9, pp. 179- 180 ,(1970) , 10.1016/0028-3908(70)90062-6
H.O.J. Collier, A Pharmacological Analysis of Aspirin Advances in pharmacology. ,vol. 7, pp. 333- 405 ,(1969) , 10.1016/S1054-3589(08)60566-9
J. Azerad, A. Woda, Sensation evoked by bipolar intrapulpal stimulation in man Pain. ,vol. 4, pp. 145- 152 ,(1977) , 10.1016/0304-3959(77)90128-2
Rita B. Messing, Loy D. Lytle, Serotonin-containing neurons: their possible role in pain and analgesia. Pain. ,vol. 4, pp. 1- 21 ,(1977) , 10.1016/0304-3959(77)90083-5
T. Hokfelt, A. Ljungdahl, L. Terenius, R. Elde, G. Nilsson, Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 3081- 3085 ,(1977) , 10.1073/PNAS.74.7.3081
MONTE S. BUCHSBAUM, GLENN C. DAVIS, WILLIAM E. BUNNEY, Naloxone alters pain perception and somatosensory evoked potentials in normal subjects Nature. ,vol. 270, pp. 620- 622 ,(1977) , 10.1038/270620A0