A double-blind placebo-controlled trial of progesterone vaginal suppositories in the treatment of premenstrual syndrome

摘要: Rigorous criteria were used to select women with severe premenstrual syndrome for inclusion in an 8-month double-blind placebo-controlled clinical trial of progesterone vaginal suppositories. Following a control month without treatment, (200 mg polyethylene glycol base) or placebo was self administered twice daily by suppository minimum 12 days before the onset menstruation 3 months. Crossover opposite medication further months followed final cycle treatment 8. Physician contact minimized throughout study avoid any possible positive effects psychological support which may have confounded past investigations. Detailed self-report questionnaires completed every duration study. Although attrition rate high, 20 and their records are analyzed here. The results this indicate that response these dosages is, at best, marginal not significantly different from use.