The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus

摘要: The complete nucleotide sequence of an infectious clone simian immunodeficiency virus macaques, SIVmac239, has been determined. Virus produced from this molecular causes AIDS in rhesus monkeys a time frame suitable for laboratory investigation. proviral genome including both long terminal repeats is 10,279 base pairs length and contains open reading frames gag, pol, vif, vpr, vpx, tat, rev, env. nef gene in-frame premature stop after the 92nd codon. At level, SIVmac239 closely related to SIVmac251 (98%) SIVmacl42 (96%). It will now be possible test which features viral are critical determinants pathogenesis AIDS.