Area-specific Modulation of Functional Cortical Activity During Block-based and Trial-based Proactive Inhibition.

摘要: Animals can suppress their behavioral response in advance according to changes environmental context (proactive inhibition: delaying the start of response), a process which several cortical areas may participate. However, it remains unclear how this is adaptively regulated contextual on different timescales. To address issue, we used an improved stop-signal task paradigm behaviorally and electrophysiologically characterize temporal aspect proactive inhibition head-fixed rats. In task, they must respond go cue as quickly possible (go trial), but did not have if stop followed (stop trial). The alternated between block only trials (G-block) go-and-stop (GS-block). We observed block-based trial-based (emerging GS-block after trial, respectively) by evaluating delay reaction time correct depending analyzed task-related neuronal activity primary secondary motor, posterior parietal, orbitofrontal cortices (M1, M2, PPC, OFC, respectively). Under inhibition, spike cue-preferring OFC neurons was attenuated continuously, while M1 M2 enhanced during motor preparation. Subsequently, decision/execution. continuously enhanced, PPC also shortly These results suggest that mechanisms underlie two types rodents.