Steroid modulation of the expression of growth factors and oncogenes in breast cancer.
作者： K. S. McCarty , K. S. McCarty
DOI: 10.1007/978-1-4615-3940-7_9
关键词:
摘要: Breast cancer, as with most cancers, is the consequence of a multistage process dependent on number independent mutational events. One critical events an escape from cell cycle control. In normal breast cells initial signal for progression estrogen modulated by progesterone. This modulates gene expression interaction its receptor (ER). The estrogen-receptor complex functions trans-acting factor targeted to specific cis-acting responsive elements (ERE) located either within or around target genes. Detailed analysis this provides insight into possible mechanisms hormone independence tumors. Estrogen part superfamily receptors (HR). interrelations these other factors, including growth factors and oncogenes, appear understanding neoplastic transformation breast, relation
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