Newborn screening for congenital heart disease using echocardiography and follow-up at high altitude in China.

摘要: Abstract Background Pulse oximetry screening for critical congenital heart disease (CHD) is inapplicable to high altitude due the variedly decreased arterial saturations and rare complex CHD. We examined incidence spectrum of CHD in newborns using echocardiography at followed up their outcomes. Methods A total 1337 babies were studied. Echocardiography was performed 1002 asymptomatic (3–5 days). In same period, retrospectively studied 394 (≤2 days) admitted NICU where echocardiograph 335. both groups, follow-up made 1–3, 6 12–18 months. Results The 27.8%, consisting secundum atrial septal defect (ASD) [175 (62.7%)], patent ductus arteriosus (PDA) [61 (21.9%)], ventricular (VSD) [8 (2.9%)] multiple defects [35 (12.6%)]. And 19.4% patients with similar spectrum, except 2 who died before discharge. By 12–18 months follow-up, 30% remained open. Thirteen developed mild severe pulmonary hypertension (PAH), them failure. Conclusions about 20 times higher than that low altitude, mostly simple forms left right shunt, 12–18 months, still 10 altitude. About 8% PAH or death. Follow-up must be reinforced order provide early intervention prevent from