Deadaption and readaptation with lactose, but no cross-adaptation to lactulose: a case of occult colonic bacterial adaptation.

摘要: The standard 3 h breath hydrogen (3hBH2) test distinguishes lactose maldigesters from digesters. However, multiple factors impact on BH2 and care is needed to exclude a priori variables. When these are controlled, negative implies lactase persistent status or nonpersistent with colonic adaptation. A case of Sicilian man who tested (lactase confirmed) an initial 50 g challenge described. It was observed that he consumed 28.1 lactose/day before testing. He subsequently underwent five additional tests in the course next 10 months. In four dose intake varied upon instruction, fifth 30 lactulose carried out. demonstrated radically decreasing intake, full unmasked. Output 3hBH2 inversely daily intake. Finally, at time when readapted lactose, there no discernible adaptation challenge. concluded 'occult' colonically adapted subjects may contribute tests. There relationship between variation results cross-adaptation used as adapting sugar.