Targeting microRNAs for immunomodulation.

摘要: microRNAs (miRNA) are small regulatory RNAs exerting pleiotropic functions in virtually any immune cell-type. Dozens of miRNAs with a known function the system constitute interesting drug targets for immunomodulation. Chemical modifications nucleic acid-based miRNA mimics and inhibitors largely solved instability issues but delivery to cells remains major challenge. However, recent success targeting acidic tumor microenvironment is very promising inflammatory diseases. Moreover, molecules being explored as an alternative. Although RNA often considered ‘undruggable’ by progress modulating through encouraging. Computational approaches even allow predictions about specific molecule/RNA interactions. Finally, clinical demonstrates that drugs work humans.