Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies
作者： Judith R Homberg , Evan J Kyzar , Adam Michael Stewart , Michael Nguyen , Manoj K Poudel
DOI: 10.1517/17460441.2016.1115834
关键词:
摘要: Introduction: Neurodevelopmental disorders (NDDs) are common and severely debilitating. Their chronic nature reliance on both genetic environmental factors makes studying NDDs their treatment a challenging task.Areas covered: Herein, the authors discuss neurobiological mechanisms of NDDs, present recommendations translational research therapy, outlined by International Stress Behavior Society. Various drugs currently prescribed to treat also represent highly diverse group. Acting various neurotransmitter physiological systems, these often lack specificity action, commonly used multiple other psychiatric conditions. There has been relatively little progress in development novel medications NDDs. Based clinical, preclinical models our cover wide range methodological approaches conceptual strategies.Expert opinion: To improve pharmacotherapy drug dis...
uq.edu.au
core.ac.uk
ru.nl参考文章(113)
Gregory M Asnis, Shari R Kohn, Margaret Henderson, Nicole L Brown, SSRIs versus non-SSRIs in post-traumatic stress disorder: an update with recommendations. Drugs. ,vol. 64, pp. 383- 404 ,(2004) , 10.2165/00003495-200464040-00004
Jeffrey R. Leonard, Barbara J. Klocke, Cleta D'sa, Richard A. Flavell, Kevin A. Roth, Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice. Journal of Neuropathology and Experimental Neurology. ,vol. 61, pp. 673- 677 ,(2002) , 10.1093/JNEN/61.8.673
A. Marten H. Onnink, Marcel P. Zwiers, Martine Hoogman, Jeanette C. Mostert, Janneke Dammers, Cornelis C. Kan, Alejandro Arias Vasquez, Aart H. Schene, Jan Buitelaar, Barbara Franke, Deviant white matter structure in adults with attention-deficit/hyperactivity disorder points to aberrant myelination and affects neuropsychological performance Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 63, pp. 14- 22 ,(2015) , 10.1016/J.PNPBP.2015.04.008
Thomas Bourgeron, From the genetic architecture to synaptic plasticity in autism spectrum disorder Nature Reviews Neuroscience. ,vol. 16, pp. 551- 563 ,(2015) , 10.1038/NRN3992
Ruthie E. Amir, Ignatia B. Van den Veyver, Mimi Wan, Charles Q. Tran, Uta Francke, Huda Y. Zoghbi, Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nature Genetics. ,vol. 23, pp. 185- 188 ,(1999) , 10.1038/13810
Marian Mellen, Pinar Ayata, Scott Dewell, Skirmantas Kriaucionis, Nathaniel Heintz, MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system Epigenetics & Chromatin. ,vol. 6, pp. 52- ,(2013) , 10.1186/1756-8935-6-S1-P52
M van der Voet, B Harich, B Franke, A Schenck, ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila Molecular Psychiatry. ,vol. 21, pp. 565- 573 ,(2016) , 10.1038/MP.2015.55
Adrian Zhubi, Edwin H. Cook, Alessandro Guidotti, Dennis R. Grayson, Epigenetic mechanisms in autism spectrum disorder. International Review of Neurobiology. ,vol. 115, pp. 203- 244 ,(2014) , 10.1016/B978-0-12-801311-3.00006-8
Nelle Lambert, Vanessa Wermenbol, Bruno Pichon, Sandra Acosta, Jelle van den Ameele, Camille Perazzolo, Diana Messina, Maria-Franca Musumeci, Barbara Dessars, Anne De Leener, Marc Abramowicz, Catheline Vilain, A Familial Heterozygous Null Mutation of MET in Autism Spectrum Disorder Autism Research. ,vol. 7, pp. 617- 622 ,(2014) , 10.1002/AUR.1396
Alexandria Wise, Luis Tenezaca, Robert W. Fernandez, Emma Schatoff, Julian Flores, Atsushi Ueda, Xiaotian Zhong, Chun-Fang Wu, Anne F. Simon, Tadmiri Venkatesh, Drosophila mutants of the autism candidate gene neurobeachin (rugose) exhibit neuro-developmental disorders, aberrant synaptic properties, altered locomotion, and impaired adult social behavior and activity patterns. Journal of Neurogenetics. ,vol. 29, pp. 135- 143 ,(2015) , 10.3109/01677063.2015.1064916