PEO-PPO-PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers.

摘要: Abstract Aiming at developing biodegradable thermo-responsive polymers that display enhanced rheological properties, a family of PEO–PPO–PEO based poly(ether ester urethane)s, was developed. The materials were produced following two-step synthetic pathway. triblocks first end-capped with LA or CL oligo(ester)s whereby pentablocks produced. Then, the different precursors chain extended using hexamethylene diisocyanate to create respective polymers. length and type block influenced behavior molecules in water, especially their viscosity versus temperature response. gelation increased from 23 °C for 20 wt% F127 solution 26 31 °C 4.4 7.5 lactoyl units, respectively. Materials containing longer units failed show any reverse thermo-responsiveness. presence oligo(ester) blocks also reduced gel 37 °C. While displayed around 28,000 Pa s, showed values 15,400 12,600 Pa s. Also, 37 °C as well decreased molecular weight increased. Finally, degradation process gels studied by monitoring body determining polymers, over time. Polymers tailored so combine high initial diverse rates, function present along polymeric backbone.