Insights into the Generation of Structural Diversity in a tRNA-Dependent Pathway for Highly Modified Bioactive Cyclic Dipeptides
作者： Tobias W. Giessen , Alexander M. von Tesmar , Mohamed A. Marahiel
DOI: 10.1016/J.CHEMBIOL.2013.04.017
关键词:
摘要: The nocazines are a newly defined family of antibacterial and cytotoxic cyclic dipeptides produced by different actinobacterial species. Here, we identify nocazine biosynthetic gene cluster in Nocardiopsis dassonvillei describe the elucidation pathway leading to members E XR334. Diketopiperazine (DKP) formation is carried out tRNA-dependent cyclodipeptide synthase (CDPS) showing an unknown product profile, while tailoring DKP-scaffold achieved through combined combinatorial action oxidase two distinct SAM-dependent O-/N-methyltransferases. Our results help illuminate logic resulting structural diversity set stage for exploring biological function modified as possible mediators host-pathogen host-parasite interactions.
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