Functional importance of palmitoyl protein thioesterase 1 (PPT1) expression by Sertoli cells in mediating cholesterol metabolism and maintenance of sperm quality.

摘要: Sertoli cells are a type of nurse cell in the seminiferous epithelium that crucial for sustaining spermatogenesis by extending nutritional and energy support to developing germ cells. Dysfunction could cause disordered reduced fertility males. In this study, we focused on expression function palmitoyl protein thioesterase 1 (PPT1), lysosomal depalmitoylating enzyme, Here, show PPT1 is responsive cholesterol treatment specific knockout Ppt1 causes male subfertility associated with poor sperm quality high ratio deformity. Specifically, deficiency leads variably accompanied abnormal lysosome accumulation increased levels Further, results adhesion epithelium, which likely be responsible as consequence declines count motility well incidence head summary, affects through regulating metabolism