An evidence-based systematic review on medical therapies for inflammatory bowel disease.

作者: Nicholas J Talley , Maria T Abreu , Jean-Paul Achkar , Charles N Bernstein , Marla C Dubinsky

DOI: 10.1038/AJG.2011.58

关键词:

摘要: Crohn ’ s disease (CD) and ulcerative colitis (UC) are chronic infl ammatory disorders of the gastrointestinal tract. Collectively they termed bowel (IBD) it is estimated that 1.5 million Americans ( 1 ) suff er from UC CD. Th eir etiologies unknown, although both thought to arise a disordered immune response gut contents in genetically predisposed individuals ). e characteristics diff erent, with CD typically causing transmural ammation occasionally associated granulomas, whereas usually confi ned mucosa. Both exhibit relapsing remitting course there signifi cant, oft en dramatic, reduction quality life during exacerbations 2 has an impact on psychological health, active IBD patients experiencing greater levels distress feelings lack sense self-control compared normal population inactive 3,4

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