Regional impairment of cortical and deep gray matter perfusion in preterm neonates with low-grade germinal matrix-intraventricular hemorrhage: an ASL study.

摘要: The long-term impact of low-grade germinal matrix-intraventricular hemorrhage (GMH-IVH) on brain perfusion has not been fully investigated. We aimed to compare cortical and deep gray matter (GM) cerebral blood flow (CBF) obtained with pseudo-continuous arterial spin labeling (pCASL), among preterm neonates without GMH-IVH full-term controls. 3T-pCASL examinations 9 healthy (mean gestational age 38.5 weeks, range 38–39) 28 studied at term-equivalent were analyzed. Eighteen presented normal MRI 30.50 weeks, 29–31) 10 according Volpe’s grading system 32 weeks, 28–34). A ROI-based mean CBF quantification was performed in 5 (frontal, parietal, temporal, insula, occipital), 4 subcortical GM regions (caudate, putamen, pallidum, thalamus) for each hemisphere. differences explored using a nonparametric analysis covariance. Low-grade hemispheres showed consistently lower all when compared neonates, after controlling the confounding effect age, postmenstrual birth weight P < .001, η2 = .394. No significant observed between GMH Healthy significantly higher than controls parietal (P = .032), temporal (P = .016), occipital cortex (P = .024), level thalamus (P = .023) caudate nucleus (P = .014). is associated posterior suggesting regional vulnerability these developing structures.