Evolution in HLA-DRB1 and major histocompatibility complex class II haplotypes of Australian aborigines definition of a new DRB1 allele and distribution of DRB 1 gene frequencies

摘要: Abstract The distribution of HLA-DRB1 alleles was studied in Australian aborigines from different parts Australia. There were significant differences the frequencies DRB1 ∗ 0412, 1409, and 1410 between Central Desert Yuendumu populations previously reported Cape York Kimberley aboriginal populations. A new DRB 1 allele, 1414, present at low frequency population, identified. 1414 appears to be closely related 1407 is proposed have arisen by intragenic recombination. novel DR-DQ haplotype, 1402-DRB3 0101-DQA1 0501-DQB1 0402, also This haplotype may ancestral 1409-DQB 0402 these presence haplotypes apparently confined suggests that evolution has occurred class II region period since colonization Australia, an estimated 50,000 years ago.