Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease.

摘要: Minimal trauma fractures in bone diseases are the result of fragility. Rather than considering fragility as being a reduced amount bone, we recognize that is changes material and structural properties bone. A better understanding contribution each component composition structure how these interact to maintain whole strength obtained by study metabolic diseases. Disorders collagen (osteogenesis imperfecta Paget's disease bone), mineral content, distribution (fluorosis osteomalacia); high remodeling (postmenopausal osteoporosis, hyperparathyroidism, hyperthyroidism) low (osteopetrosis, pycnodysostosis); other (idiopathic male corticosteroid-induced osteoporosis) produce abnormalities lead Observations patients animal models provide insights on biomechanical consequences illnesses nature qualities determine its strength.