Asymmetric synthesis of bb-3497—A potent peptide deformylase inhibitor
作者： Lisa M Pratt , R.Paul Beckett , Stephen J Davies , Steven B Launchbury , Andrew Miller
DOI: 10.1016/S0960-894X(01)00509-1
关键词:
摘要: By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as potent inhibitor Escherichia coli peptide deformylase with antibacterial activity both in vitro and vivo. The homochiral synthesis BB-3497, involving novel asymmetric Michael addition reaction is described.
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