Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.
作者： J G Maring , A B P van Kuilenburg , J Haasjes , H Piersma , H J M Groen
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摘要: Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for mutant allele of the DPYD gene
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Robert B. Diasio, Glen D. Heggie, Jean-Pierre Sommadossi, David S. Cross, William J. Huster, Clinical Pharmacokinetics of 5-Fluorouracil and Its Metabolites in Plasma, Urine, and Bile Cancer Research. ,vol. 47, pp. 2203- 2206 ,(1987)
Robert B. Diasio, Nicolas Albin, Kangshang Wang, Martin R. Johnson, Silke Tillmanns, Silke Tillmanns, Structural organization of the human dihydropyrimidine dehydrogenase gene. Cancer Research. ,vol. 57, pp. 1660- 1663 ,(1997)
Robert B. Diasio, Ruiwen Zhang, Zhihong Lu, Dihydropyrimidine Dehydrogenase Activity in Human Peripheral Blood Mononuclear Cells and Liver: Population Characteristics, Newly Identified Deficient Patients, and Clinical Implication in 5-Fluorouracil Chemotherapy Cancer Research. ,vol. 53, pp. 5433- 5438 ,(1993)
H M Pinedo, G F Peters, Fluorouracil: biochemistry and pharmacology. Journal of Clinical Oncology. ,vol. 6, pp. 1653- 1664 ,(1988) , 10.1200/JCO.1988.6.10.1653
M C Etienne, J L Lagrange, O Dassonville, R Fleming, A Thyss, N Renée, M Schneider, F Demard, G Milano, Population study of dihydropyrimidine dehydrogenase in cancer patients. Journal of Clinical Oncology. ,vol. 12, pp. 2248- 2253 ,(1994) , 10.1200/JCO.1994.12.11.2248
L Zoetekouw, H R Waterham, D J Richel, A B van Kuilenburg, F Baas, J Haasjes, R Meinsma, A H van Gennip, E W Muller, Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency. Clinical Cancer Research. ,vol. 7, pp. 1149- 1153 ,(2001)
Rüdiger E. Port, Lutz Edler, Richard Herrmann, Uwe Feldmann, Pharmacokinetics of 5-fluorouracil after short systemic infusion: plasma level at the end of the distribution phase as an indicator of the total area under the plasma concentration-time curve. Therapeutic Drug Monitoring. ,vol. 13, pp. 96- 102 ,(1991) , 10.1097/00007691-199103000-00002
R.Hugh Dunstan, Stephen P. Ackland, Madhu B. Garg, Simultaneous Determination of Dihydrofluorouracil and 5-Fluorouracil in Plasma by High-Performance Liquid Chromatography Analytical Biochemistry. ,vol. 246, pp. 79- 85 ,(1997) , 10.1006/ABIO.1996.9943
RA Fleming, GA Milano, M-C Etienne, N Renée, A Thyss, M Schneider, F Demard, No effect of dose, hepatic function, or nutritional status on 5-FU clearance following continuous (5-day), 5-FU infusion. British Journal of Cancer. ,vol. 66, pp. 668- 672 ,(1992) , 10.1038/BJC.1992.335
P.K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson, D.C. Klenk, Measurement of protein using bicinchoninic acid Analytical Biochemistry. ,vol. 150, pp. 76- 85 ,(1985) , 10.1016/0003-2697(85)90442-7