Molecular Targets of Chemotherapeutic Agents Against the Human Immunodeficiency Virus

摘要: There are a multitude of virus-specific proteins and steps in the replicative cycle human immunodeficiency virus (HIV) that could act as targets for potential drugs against acquired immune deficiency syndrome (AIDS). The reverse transcriptase has proven to be principal if not sole target anti-HIV activity 2′ ,3′-dideoxynucleoside analogues [ie. 3′-azido-2′,3′-dideoxythymidine (AZT), 2′,3′-dideoxycytidine (DDC) 2′,3′-didehydro-2′,3′-dideoxythymidine (D4T)], following intracellular phosphorylation these nucleoside their 5′-triphosphates. Sulfated polysaccharides such heparin, dextran sulfate pentosan polysulfate block adsorption outer cell membrane, which implies compounds do have taken up by cells achieve activity. Several other viral processes (i.e. uncoating, integration, transcription assembly) protease, tat protein, refprotein RNase H) been identified attractive antiviral chemotherapy, an intensive search specific inhibitors functions continues.