Cyclic AMP and permeability coefficient of albumin of the isolated rat mesentery. Effects of Escherichia coli endotoxin.
作者： Etienne Brachet , André Kahn
DOI: 10.1016/0304-4165(81)90481-5
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摘要: Abstract We have investigated the mechanisms whereby Escherichia coli endotoxin exerts its exudative effects, by using an isolated rat mesentery placed as a separation membrane between two compartments of diffusion cell. The permeability coefficient albumin ( P A ) can be easily computed from equilibration rate 125 I-labeled added to one compartment. E. increased in concentration-related manner. Direct measurements revealed early and transient increase cyclic AMP prostaglandin E-immunoreactive material. These effects could inhibited indomethacin. Calcium-depleted tissues low , even though levels still endotoxin. If incubations were prolonged beyond 90 min, remained elevated, but E fell control values. Similar results observed with trypsin-treated tissues. suggest that transmesenteric passage is presence During earlier part incubation (up min), related local synthesis E, are controlled intracellular calcium levels. longer (90–280 min) mesothelial exfoliation occur, allowing free through remaining interstitial tissue.
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Henry Z. Movat, Inflammation, immunity, and hypersensitivity ,(1971)
Alton L. Steiner, Anthony S. Pagliara, Lewis R. Chase, David M. Kipnis, Radioimmunoassay for cyclic nucleotides. II. Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mammalian tissues and body fluids. Journal of Biological Chemistry. ,vol. 247, pp. 1114- 1120 ,(1972) , 10.1016/S0021-9258(19)45622-6
Ann M. Northover, B. J. Northover, The effects of histamine, 5-hydroxytryptamine and bradykinin on rat mesenteric blood vessels The Journal of Pathology. ,vol. 98, pp. 265- 276 ,(1969) , 10.1002/PATH.1710980406
J.R. Fletcher, Peter W. Ramwell, Clifford M. Herman, Prostaglandins and the Hemodynamic Course of Endotoxin Shock Journal of Surgical Research. ,vol. 20, pp. 589- 594 ,(1976) , 10.1016/0022-4804(76)90095-0
R. J. Jones, E. A. Roe, Measurement of endotoxins with the limulus test in burned patients. Journal of Hygiene. ,vol. 83, pp. 151- 156 ,(1979) , 10.1017/S0022172400025924
G. Majno, G. E. Palade, Gutta I. Schoefl, STUDIES ON INFLAMMATION The Journal of Biophysical and Biochemical Cytology. ,vol. 11, pp. 607- 626 ,(1961) , 10.1083/JCB.11.3.607
C. C. Berdjis, Endotoxin and Traumatic Shock: Role of the Capillaries and Small Blood Vessels JAMA. ,vol. 204, pp. 191- 194 ,(1968) , 10.1001/JAMA.204.3.191
Gayle P. Orczyk, Harold R. Behrman, Ovulation blockade by aspirin or indomethacin--in vivo evidence for a role of prostaglandin in gonadotrophin secretion. Prostaglandins. ,vol. 1, pp. 3- 20 ,(1972) , 10.1016/0090-6980(72)90061-5
J.P. Famaey, J. Fontaine, I. Seaman, J. Reuse, A possible role of prostaglandins in guinea-pig isolated ileum contractions to serotonin Prostaglandins. ,vol. 14, pp. 119- 124 ,(1977) , 10.1016/0090-6980(77)90160-5
Arnold G. Herman, John R. Vane, Release of renal prostaglandins during endotoxin-induced hypotension. European Journal of Pharmacology. ,vol. 39, pp. 79- 90 ,(1976) , 10.1016/0014-2999(76)90115-1