The interaction of Wnt-11 and signalling cascades in prostate cancer

摘要: Prostate cancer (PCa) is the second most common among male population. Conventional therapies target androgen signalling, which drives tumour growth; however, they provide limited survival benefits for patients. It essential, therefore, to develop a more specific biomarker than current gold standard, PSA testing. The Wnt signalling pathway induces expression of genes through cell surface receptors. A non-canonical member this family, Wnt-11, evolutionarily highly conserved and normally expressed by various cells in developing embryo, as well heart, liver skeletal muscle adult humans. We comprehensively review several pathways explain how interact with demonstrating its use potential PCa. Several studies have shown that Wnt-11 associated gastric, renal colorectal adenocarcinomas Moreover, affects extracellular matrix composition cytoskeletal rearrangement, it required proliferation and/or during differentiation. was found PCa lines express high levels allows differentiation epithelial prostate neuron-like (NE) cells. NE produce additional factors can cause regression after treatment. Accumulating evidence shows could be diagnosing Many both canonical Wnts cascades such PKC, JNK, NF-κB, Rho, PKA PI3K. In particular, demonstrates involved progression PCa, thus become disease marker an important therapeutic target.