LACK OF PERSON-TO-PERSON TRANSMISSION OF ENTEROTOXIGENIC ESCHERICHIA COLI DESPITE CLOSE CONTACT

摘要: The scanty epidemiologic evidence available suggests that enterotoxigenic Escherichia coli (ETEC) are usually spread by contaminated food and water vehicles; little is known of the risk secondary contact transmission. Studies carried out in a 22-bed isolation Ward at U. Maryland Hospital gave opportunity to determine whether individuals excreting ETEC, with without diarrhea, would transmit pathogen controls living close contact. In one combined study, seven volunteers who had ingested 10(8) virulent ETEC (strain H10407), were housed day night for two weeks eight other volunterrs participating an intranasal attenuated influenza vaccine study. second four persons ingesting 214-4) lived 13 inoculated vaccine. E. groups randomly mixed bedrooms shared bathrooms, dining recreation areas ward. Seven developed diarrhea; all 11 excreted (10(7)-10(9) organisms/gm or ml stool), 10 significant rises anti-O antitoxin antibody. contrast, no vaccinees, despite sharing facilities, antibody antigens. These data suggest not readily transmitted healthy adults direct person-to-person Precautions prevent contamination sources appear be most rational intervention avoid cases diarrhea.