SPECT perfusion imaging in the diagnosis of Alzheimer’s disease: A clinical-pathologic study

摘要: Objective: Numerous studies have suggested that temporoparietal hypoperfusion seen on brain imaging with SPECT may be useful in diagnosing AD during life. However, these often been limited by lack of pathologic validation and unrepresentative samples. The authors performed this study to determine whether provides diagnostically information addition obtained from a clinical examination. Methods: Clinical data images were collected prospectively, patients followed autopsy. history, findings, each evaluated raters blind other features, diagnoses compared diagnoses. population consisted 70 dementia, autopsy; 14 controls 71 (no autopsy performed). primary outcome was the likelihood diagnosis given positive diagnosis, both. Results: When all participants (patients controls) included analysis, “probable” associated an 84% AD. A scan raised 92%, whereas negative lowered 70%. more when “possible” AD, 67% without SPECT, 52% SPECT. Similar results found only dementia analysis. Conclusions: In evaluation can provide clinically indicating presence is evaluation.