DNA glycosylases search for and remove oxidized DNA bases
作者： Susan S. Wallace
DOI: 10.1002/EM.21820
关键词:
摘要: The following mini review summarizes recent research from the Author’s laboratory as presented to Environmental Mutagen Society in October 2012. It provides an overview of DNA glycosylases that recognize oxidized bases using Fpg/Nei family models for how structure can inform function. For example, even though human NEIL1 and plant fungal orthologs lack zinc finger shown be required binding, crystal structures revealed a “zincless finger” with same properties. Also “lesion recognition loop” is not involved lesion rather stabilization 8-oxoG active site pocket. Unlike other members, Neil3 lacks two three void-filling residues stabilize duplex interact opposite strand which may account its preference lesions single stranded DNA. We also showed, molecule approaches, search their substrates sea undamaged by wedge residue inserted into helix probe presence damage.
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