Galleria mellonella as a model host to study gut microbe homeostasis and brain infection by the human pathogen listeria monocytogenes
作者： Krishnendu Mukherjee , Ramya Raju , Rainer Fischer , Andreas Vilcinskas
DOI: 10.1007/10_2013_203
关键词:
摘要: The gastrointestinal tract in both mammals and insects is associated with microbes (collectively the microbiota), which are controlled by intestinal immune system. These regulate pathogens that can infect gut epithelial cells, there increasing evidence for a reciprocal relationship between beneficial pathogenic bacteria Deciphering these complex interactions microbiota system requires surrogate model systems, such as larvae of greater wax moth Galleria mellonella. exposure G. mellonella to antibiotics induces immunity stress-related genes intestine. also provide insight into virulence mechanisms Listeria monocytogenes human brain. We discuss current uses develop therapeutic strategies against listeriosis.
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