Brain connectivity and prediction of relapse after cognitive-behavioral therapy in obsessive-compulsive disorder.

摘要: Background: Intensive cognitive-behavioral therapy can effectively reduce symptoms in obsessive-compulsive disorder (OCD). However, many relapse after treatment. Few studies have investigated biological markers predictive of follow-up clinical status. The objective was to determine if brain network connectivity patterns prior intensive predict worsening clinic during follow-up. Methods: We acquired resting-state functional magnetic resonance imaging data from 17 adults with OCD and following 4 weeks therapy. Functional were analyzed yield graph theory metrics. examined the relationship between pre-treatment connectome properties before treatment a 12-month period. Results: Mean symptom decrease 40.4±16.4% pre- post-treatment (64.7% responded; 58.8% remitted), but 35.3% experienced clinically significant From post-treatment, small-worldness clustering coefficient significantly increased. Decreases modularity correlated decreases symptoms. Higher small-world associated Psychometric neurocognitive measures not predictors. Conclusions: This is first study effects OCD, test associations Results show efficiency as biomarker response OCD. Cognitive-behavioral increases it alleviates most patients, those entering already high are at greater risk relapse. potential implications for selection.