Pimarane-type Diterpenes Obtained by Biotransformation: Antimicrobial Properties Against Clinically Isolated Gram-positive Multidrug-resistant Bacteria
作者： Thiago S. Porto , Marília R. Simão , Lucas Z. Carlos , Carlos H. G. Martins , Niege A. J. C. Furtado
DOI: 10.1002/PTR.4887
关键词:
摘要: The present study describes the antimicrobial activity of five pimarane-type diterpenes obtained by fungal biotransformation against several nosocomial multidrug-resistant bacteria. Among investigated metabolites, ent-8(14),15-pimaradien-3β-ol was most active compound, with very promising minimal inhibitory concentration values (between 8.0 and 25.0 µg mL−1). Time-kill assays using this metabolite Staphylococcus aureus (HCRP180) revealed that compound exerted its bactericidal effect within 24 h at all evaluated concentrations (8.0, 16.0, 24.0 When associated vancomycin their values, resulting combination able to drastically reduce number viable strains S. first 6 h, compared these chemicals alone. checkerboard conducted microorganism did not evidence any synergistic effects when same employed. In conclusion, our results point out is an important in search for new effective agents. Copyright © 2012 John Wiley & Sons, Ltd.
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