Microbial Interactions in Oral Communities Mediate Emergent Biofilm Properties.

摘要: Oral microbial communities are extraordinarily complex in taxonomic composition and comprise interdependent biological systems. The bacteria, archaea, fungi, viruses that thrive within these engage extensive cell-cell interactions, which both beneficial antagonistic. Direct physical interactions among individual cells mediate large-scale architectural biofilm arrangements provide spatial proximity for chemical communication metabolic cooperation. In this review, we summarize recent work identifying specific molecular components describe such as cross-feeding exchange of electron acceptors small molecules, modify the growth virulence species. We argue, however, although pairwise interaction models have provided useful information, community-like systems needed to study properties oral communities. networks multiple synergistic antagonistic biofilms give rise emergent persistence, stability, long-range structure, with mediating dysbiotic transitions from health diseases. A better understanding fundamental interspecies will lead development effective strategies manipulate