Predictors of Chemotherapy-Induced Peripheral Neuropathy

作者: Yuko Kanbayashi , Toyoshi Hosokaw

DOI: 10.5772/27563

关键词:

摘要: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of chemotherapy that often develops in response to administration various drugs, including, molecularly targeted therapeutic agents (bortezomib), taxanes (paclitaxel, docetaxel), platinum compounds, platinum-containing drugs (cisplatin, carboplatin, oxaliplatin), vinca alkaloids (vincristine), thalidomide, lenalidomide, and epothilones (ixabepilone) (Kannarkat et al., 2007; Ocean 2004; Park al.,2008; Walker Windebank 2008; Wolf 2008). It has been postulated CIPN may represent the initial stage development neuropathic pain. Although symptoms are diverse, condition consistently reduces patient quality life (QOL). Unfortunately, effective strategies for preventing or treating remain elusive. To identify significant predictors which would contribute improving QOL among patients, we conducted study, entitled, "Statistical identification associated with bortezomib, taxanes, oxaliplatin vincristine using ordered logistic regression analysis" (Kanbayashi 2010). In this review, will discuss review other studies.

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