Cytokines in rheumatoid arthritis. Potential targets for pharmacological intervention.

摘要: The ingress of inflammatory leucocytes into the synovium is a crucial step in pathogenesis rheumatoid arthritis (RA). Cytokines are mediators involved events, adhesive mechanisms, angiogenesis and osteopenia associated with RA. Pro- anti-inflammatory cytokines, growth factors chemokines all have an important role these processes. Because efficacy currently used antirheumatic therapy often limited, there need for more specific intervention strategies. Anticytokine may include use monoclonal antibodies, antagonistic soluble cytokine receptors, receptor antagonists, somatic gene transfer or other approaches. Hopefully, study cytokines their interactions will lead to development new immunomodulatory strategies that benefit patients