Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents

作者： Xuliang Lang , Lulu Li , Yuzong Chen , Qinsheng Sun , Qin Wu

DOI: 10.1016/J.BMC.2013.05.008

关键词:

摘要: Acridine derivatives have been explored as DNA-binding anticancer agents. Some show undesired pharmacokinetic properties and new need to be explored. In this work, a series of novel acridine analogues were synthesized by modifying previously unexplored linkers between the benzene groups their antiproliferative activity ability evaluated. Among these derivatives, compound 5c demonstrated capability topoisomerase I inhibitory activity. K562 cell lines, induced apoptosis through mitochondria-dependent intrinsic pathways. These data suggested that other with modified might potent

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Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents

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Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents

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