Long-term clinical parameters after switching to nocturnal haemodialysis: a Dutch propensity-score-matched cohort study comparing patients on nocturnal haemodialysis with patients on three-times-a-week haemodialysis/haemodiafiltration

摘要: Objectives Nocturnal haemodialysis (NHD), characterised by 8-hour sessions ≥3 times a week, is known to improve clinical parameters in the short term compared with conventional-schedule (HD), generally 3×3.5–4 hours week. We studied long-term effects of NHD and used patients on conventional HD/haemodiafiltration (HDF) as controls. Design Four-year prospective follow-up who switched NHD; we HD/HDF using propensity score matching. Setting 28 Dutch dialysis centres. Participants included 159 starting any time since 2004, aged 56.7±12.9 years, median vintage 2.3 (0.9–5.1) years. propensity-score matched 100 HD/HDF. Primary secondary outcome measures Control hypertension (predialysis blood pressure, number antihypertensives), phosphate (phosphate, binders), nutritional status inflammation (albumin, C reactive protein postdialysis weight) anaemia (erythropoiesis-stimulating agent (ESA) resistance). Results Switching was associated non-significant reduction antihypertensives (OR Conclusions After switching NHD, lower need for antihypertensives, binders ESA persists at least 4 These sustained improvements contrast significantly course these during continued treatment HD HDF. provides an optimal form dialysis, also suitable expected have long waiting transplantation or those convicted indefinite dialysis.