Patterns of hepatitis B prevalence and seroconversion in hemodialysis units from three continents: The DOPPS

摘要: Background. Hepatitis C virus (HCV) remains a problem within hemodialysis units. This study measures HCV prevalence and seroconversion rates across seven countries investigates associations with facility-level practice patterns. Methods. The sample was from the Dialysis Outcomes Practice Patterns Study (DOPPS), prospective, observational of adult patients randomly selected 308 representative dialysis facilities in France, Germany, Italy, Japan, Spain, United Kingdom, States. Logistic regression used to model odds prevalence, Cox time entry seroconversion. Results. Mean facility 13.5% varied among 2.6% 22.9%. Increased associated longer on dialysis, male gender, black race, diabetes, hepatitis B (HBV) infection prior renal transplant, alcohol or substance abuse previous 12 months. Approximately half (55.6%) had no seroconversions during period. human immunodeficiency virus/acquired syndrome (HIV/AIDS), HBV infection, recurrent cellulitis gangrene. An increase highly trained staff lower (OR=0.93 per 10% increase, P=0.003) risk (RR=0.92, P=0.07). Seroconversion an (RR=1.36, P<0.0001), but not isolation HCV-infected (RR=1.01, P=0.99). Conclusion. There are differences rate at country level. observed variation suggests opportunities for improved outcomes.