The effect of apamin on the smooth muscle cells of the guinea-pig taenia coli
作者： Ad J.J. Maas , Adriaan Den Hertog
DOI: 10.1016/0014-2999(79)90006-2
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摘要: Abstract The polypeptide apamin caused a small depolarization of the muscle cell membrane guinea-pig taenia coli accompanied by enhancement spike activity and concomitant contraction. hyperpolarization evoked intramural stimulation non-adrenergic inhibitory nerves (inhibitory junction potential) was reduced apamin; antagonism being non-competitive in nature. rebound contraction following potential enhanced apamin. induced purinergic compound ATP sympathomimetic adrenaline converted to presence This resulted an increased followed relaxation after washout drugs. These findings indicate that is non-competitive, non-specific antagonist transmitter are mutually independent phenomena.
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