The Insulin-Like Growth Factors and Assessment of Nutritional Status

摘要: The regulation of circulating IGF-I and IGFBPs by nutritional intake the short half-life these proteins in circulation offer great potential for IGF to be utilized as exceptionally sensitive acute biochemical markers intake, repletion, metabolic status. The value serum an indicator short-term response nutrional intervention has been described a wide variety patient populations experimental conditions. The sensitivity specificity marker status critical illness is much greater than other visceral such albumin, retinol binding protein, or transthyretin. Continued validation disorders anticipated since assessment appropriate both exceedingly important particularly challenging circumstances. Because nature nutrition, IGFs are less suited evaluating chronic status, body weight, composition. The dependence on vitamins, minerals, dietary constituents fully investigated; however, deficiencies specific nutrients clearly influence protein synthesis concentrations serum. The IGFBPs, particular IGFBP-1, IGFBP-2, perhaps ratios IGF-I, free relation await further study, but could prove valuable status.