Overview of the development of quinolone resistance in Salmonella species in China, 2005-2016.

摘要: Purpose Several factors contribute to the complexity of quinolone resistance in Salmonella, including >2000 different Salmonella serotypes, a variety hosts for and wide use quinolones human beings animals. We thus aimed obtain an overview development relevant molecular mechanisms such species. Materials methods A total 1,776 isolates were collected Ningbo, China, between 2005 2016. Antimicrobial susceptibility genetic these retrospectively analyzed. Results The ratio ciprofloxacin (CIP) resistant:reduced CIP susceptible:CIP susceptible was 26:522:1,228. found nine 51 serotypes: Derby, London, Kentucky, Indiana, Corvallis, Rissen, Hadar, Typhimurium, Agona. Of 26 CIP-resistant isolates, all concurrently resistant ampicillin 21 also cefotaxime produced extended-spectrum β-lactamase (ESBL). minimal inhibitory concentration values at three levels: 2-4 μg/mL (serotypes except Kentucky Indiana), 16 (one isolate), >32 (Indiana isolates). As with most common Typhi showed quickly increased prevalence reduced recent years, Enteritidis remained high throughout study period, several Typhimurium CIP. Transferable plasmid-mediated gene qnrB only isolates. In contrast, gyrA mutations often CIP-susceptible not necessarily Conclusion conclude that there exists low resistance, which focuses on serotypes. Our demonstrates that, rather than mutations, is indicator resistance.