Therapeutic Uses of Cholinesterase Inhibitors in Neurodegenerative Diseases

摘要: Publisher Summary The chapter describes the rationale for therapies in Alzheimer's disease (AD), aspects of their application to clinical disease, and what is learned from effects drugs neurodegenerative disease. Effective preventive therapeutic strategies AD other age-related diseases are most pressing need modern neurological practice. multifactorial nature etiology sporadic seems imply a likelihood that effective treatment will target several or many these processes. Indeed, models progression invoke self-reinforcing cycles cerebral damage may be checked part at any one number steps, but best approached by multiple pathogenesis. Definitive experimental evidence role ACh pathogenesis human prove elusive, perhaps unambiguously manifest only context cotreatments with AChEIs agents symptomatic alone dictate they remain important treatments AD.