Risk factors for HIV-1 infection in adults in a rural Ugandan community: a case-control study

摘要: The authors sought to study in depth the sexual history and behavior variables considered risk factors for HIV-1 infection a rural Ugandan population. Following socioeconomic serological survey of population Masaka District southwest Uganda 233 randomly selected positive cases negative controls matched on age village residence were invited October 1990 participate case-control study. A total 132 161 attended in-depth investigation including an interview about behavior. factor which was most strongly associated with increased greater number lifetime partners odds ratios (OR) 2.1 4.9 those reporting 4 10 11 or more respectively compared less than partners. Having only 1 partner did not provide complete protection 7 (1 male 6 female) subjects positive. Other significant genital ulcers (OR 2.9; 95% confidence intervals [CI] 1.0 9.1) being Muslim 5.4; CI 1.8 16.5) suggesting possible protective effect circumcision. There suggestion that who married within last years 2.4; 0.9 6.1) men exposed menstrual blood 5.7; 0.7 49.8) at infection. These results confirm predominant role epidemic. Of particular concern is observance among partner. Where widely distributed general reduction strategies should addition promotion place strong emphasis safe-sex techniques. (authors)