Neuronal abnormalities in microtubule-associated protein 1B mutant mice

摘要: Abstract Microtubules play an important role in establishing cellular architecture. Neuronal microtubules are considered to have a dendrite and axon formation. Different portions of the developing adult brain associated with different microtubule-associated proteins (MAPs). The roles each MAPs not well understood. One these proteins, MAP1B, is expressed has been postulated neuronal plasticity development. To ascertain we generated mice which carry insertion gene by gene-targeting methods. Mice homozygous for modification die during embryogenesis. heterozygotes exhibit spectrum phenotypes including slower growth rates, lack visual acuity one or both eyes, motor system abnormalities. Histochemical analysis severely affected revealed that their Purkinje cell dendritic processes abnormal, do react MAP1B antibodies, show reduced staining MAP1A antibodies. Similar histological immunochemical changes were observed olfactory bulb, hippocampus, retina, providing basis phenotypes.