The structural basis for the allosteric regulation of ribonucleotide reductase.
作者： Md. Faiz Ahmad , Chris G. Dealwis
DOI: 10.1016/B978-0-12-386931-9.00014-3
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摘要: Ribonucleotide reductases (RRs) catalyze a crucial step of de novo DNA synthesis by converting ribonucleoside diphosphates to deoxyribonucleoside diphosphates. Tight control the dNTP pool is essential for cellular homeostasis. The activity enzyme tightly regulated at S-phase allosteric regulation. Recent structural studies our group and others provided molecular basis understanding how RR recognizes substrates, it interacts with chemotherapeutic agents, its regulators ATP dATP. This review discusses regulation substrate recognition RR, particularly discovery that subunit oligomerization an important prerequisite in inhibition.
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