The triglyceride to high-density lipoprotein-cholesterol ratio in adolescence and subsequent weight gain predict nuclear magnetic resonance-measured lipoprotein subclasses in adulthood.

摘要: Objective To assess whether the fasting triglyceride–to–high-density lipoprotein (HDL)–cholesterol (TG/HDL) ratio in adolescence is predictive of a proatherogenic lipid profile adulthood. Study design A longitudinal follow-up 770 Israeli adolescents 16 to 17 years age who participated Jerusalem Lipid Research Clinic study and were reevaluated 13 later. Lipoprotein particle size was assessed at with proton nuclear magnetic resonance. Results The TG/HDL measured strongly associated low-density lipoprotein, very low–density (VLDL), HDL mean young adulthood both sexes, even after adjustment for baseline body mass index change. subsequent weight gain independently predicted atherogenic small large VLDL concentrations ( P Conclusions Adolescents an elevated are prone express This additionally worsened by gain.