Cellular responses during liver fluke infection in sheep and its evasion by the parasite

摘要: Summary The cellular immune response in sheep to an acute and chronic primary secondary liver fluke infection were examined by immunohistology of tissue flowcytometry lymphocytes from the draining hepatic lymph nodes. Ten days after infection, portal tract areas surrounding migratory tunnels infiltrated with CD4+ CD8+ fewer B cells T19+ T cells. Micro abscesses distributed sporadically parenchyma young flukes could be easily observed free inflammatory More intensive infiltration was during a characterized pronounced increase eosinophils, In addition, there MHC class II+ fibroblastic-like tracts. contrast no same infection. Chronic infections perilobular fibrosis predominance γδ-TCR+ T19- within fibrotic strands. Distinct cell follicles strands near major bile ducts necrotic patches. Pronounced lymphocyte occasionally eggs lodged tissue. A progressive node weight, number CD4/CD8 ratio infections. The role infiltrating populations possible mechanisms evasion parasite are discussed.