Presence of haptoglobin-2 allele is associated with worse functional outcomes after spontaneous intracerebral hemorrhage.

摘要: Objective To determine if the haptoglobin (Hp) phenotype, which has been shown to be a predictor of clinical outcomes in cerebrovascular disorders, particularly subarachnoid hemorrhage, was predictive functional after spontaneous intracerebral hemorrhage (ICH). Methods Patients admitted with diagnosis ICH were prospectively included and divided into 3 groups based on their genetically determined Hp phenotype: 1-1, 2-1, 2-2. Outcome measures mortality 30-day modified Rankin Scale scores. Demographics compared for each phenotype using multivariate linear regression analysis. Results The study 94 patients. distribution 12 (13%); 46 (49%); 2-2, 36 (38%). subgroups did not differ terms demographic variables, comorbidities, or characteristics. There nonsignificant trend toward increased 2-1 2-2 8% 17% 25% ( P  = 0.408). In model adjusted confounders, (odds ratio = 0.05, 95% confidence interval = 0.01–0.47, 0.045) had significantly lower odds scores 0–2 1-1. Conclusions After ICH, individuals Hp-2 allele (2-1 2-2) worse than Hp-1 (Hp 1-1). association between mortality. Larger prospective studies better surrogates are warranted.