The enigmatic processing and secretion of interleukin-33.

摘要: Interleukin-33 (IL-33) is the most attractive novel cytokine identified as an IL-1 family member. IL-33 was first named NF-HEV (nuclear factor from high endothelial venules), it known to interact with nuclear chromatin although its exact intracellular functions are still be clarified. now recognized specific ligand for orphan receptor member ST2 and involved in polarization of T cells towards helper 2 cell phenotype activation mast cells, bosophils, eosinophils natural killer cells. It essential extracellularly released order bind consequently play a crucial role inflammatory, infectious autoimmune diseases. However, like members, IL-1beta IL-18, mRNA translated without signal sequence secretion. Additionally, cannot by processing secretion mechanism shared IL-18 not substrate caspase-1 does require proteolysis activation. In contrast, can inactivated apoptotic caspases. Accordingly, proposed alarmin necrotic but deleted during apoptosis. Besides autocrine, paracrine, intracrine, juxtacrine retrocrine mechanisms cellular interaction cytokines, release another pathway display function, which we suggest might called 'necrocrine'. This mini review summarizes recent progress how displays potential immunoregulatory roles particular focus on enigmatic production.