Influence of Total Diet on Calcium Homeostasis

摘要: Changes in dietary practices offer a sensible, food-based, low-cost approach for modification of risk factors and prevention osteoporosis. However, defining the effects diet on bone health has not been simple task becauseof following reasons: 1. Bone is complex. Bone composite material with both organic inorganic components. By weight, 70% mineral 5C8% water, rest material. The phase approx 95% calcium hydroxyapatite arranged plate-like crystals; primarily proteins 98% type I collagen, plus variety noncollagenous including important regulatory proteins, cytokines, growth (1).This specialized, vital, metabolically active, connective tissue provides only structural framework, protection vital organs, locomotion, hematopoesis, but also serves as buffering reservoir aids kidneys lungs tight regulation body’s hydrogen ion concentration. This latter metabolic function received considerable attention area nutrition research health. 2. Food In addition to energy, food host essential nutrients bioactive nonnutrients multifaceted functions interactions. These components can affect homeostasis through direct effect acidCbase balance, systemic or cellular processes. Previously, bulk studies investigating metabolism have focused influence single homeostasis. strength this reductionistic that it affords investigation specific role mechanism action given nutrient; however, does address various interactions between result when we consume whole foods mixed diet. 3. The body complex adaptable. response stimuli spans entire range from localized responses such changes osteoblast and/or osteoclast activity paracrine/autocrine signals, systemic, whole-body renal excretion, endocrine (hormonal/growth factor) changes. recent observations acid excretion adapts over time point often understated quality human body—its innate capability adapt stimulus time.