Interventions for the treatment of uveitic macular edema: a systematic review and meta-analysis

摘要: Background Uveitic macular edema is the major cause of reduced vision in eyes with uveitis. Objectives To assess effectiveness interventions treatment uveitic edema. Search strategy Cochrane Central Register Controlled Trials, Medline, and Embase. There were no language or data restrictions search for trials. The databases last searched on December 1, 2011. Reference lists included trials searched. Archives Ophthalmology, Retina, British Journal New England Medicine clinical reviews. Selection criteria Participants any age sex type included. Early, chronic, refractory, secondary We that compared dose duration, including comparison another treatment, sham treatment. Data collection analysis Best-corrected visual acuity central thickness primary outcome measures. Secondary adverse effects collected. Conclusion More results from randomized controlled long follow-up periods are needed to assist determining overall long-term benefit different treatments. only intervention sufficiently robust a meta-analysis was acetazolamide, which shown be ineffective improving edema, clinically now rarely used. Interventions showing promise this disease include dexamethasone implants, immunomodulatory drugs anti-vascular endothelial growth-factor agents. When has become refractory after multiple interventions, pars plana vitrectomy could considered. pathophysiology uncertain course unpredictable. As there clear guidelines literature, should tailored individual patient.