Early and delayed prediction of axillary lymph node neoadjuvant response by (18)F-FDG PET/CT in patients with locally advanced breast cancer.

摘要: To determine the utility of 18F-FDG (FDG) PET/CT performed in an early and delayed phase during neoadjuvant chemotherapy prediction lymph node histopathological response patients with locally advanced breast cancer. FDG studies 76 (mean age 53 years) at baseline (PET-1), after second course (PET-2) last (PET-3) were prospectively analysed. Inclusion criteria involvement detected by non-sentinel biopsy before or scan. Following recommendations 12th International Breast Conference (St. Gallen), divided into five subgroups relation to biological prognostic factors immunohistochemistry. For diagnosis visual semiquantitative analyses was performed. Absence detectable uptake on PET-2 PET-3 scan respect PET-1 considered metabolic complete (mCR). Lymph nodes histopathologically classified according regression grade groups as pathological (pCR) not pCR (type A/D B/C Smith grading system, respectively). ROC analysis a cut-off value Δ% SUV1–2 SUV1–3 for nodal status chemotherapy. An association between mCR found (Cohen’s kappa analysis), associations phenotypes behaviour final also found. seen 34 patients. The sensitivity, specificity, positive negative predictive values establishing axilla 52 %, 45 %, 50 % 47 %, 33 %, 84 %, 67 % 56 %, respectively. No significant relationship observed (p = 0.31 0.99, metabolism able predict status, whereas basal carcinomas showed higher rate (70.6 %) than other (p = 0.03). seems have limitations both evaluation chemotherapy, reduced values.