Trans fatty acid effects in experimental atherosclerosis

摘要: Trans unsaturated fatty acids are formed during hydrogenation of edible oils and their consumption in the United States has increased with increasing utilization margarines. The effect elaidic acid trielaidin on atherosclerosis cholesterol-fed rabbits were studied many years ago by Weigensberg McMillan, who found these to be significantly more hypercholesterolemic but not atherogenic. Jackson et al. have that trans inordinately atherogenic swine. We fed semipurified, cholesterol-free diets containing either 3.2 or 6.0% acid. slightly hyperlipidemic no than control diet. measured activities five hepatic enzymes (glucose-6-phosphatase, synthetase, malate dehydrogenase, beta-hydroxybutyrate monoamine oxidase [EC 1.4.3.4]). affected only activity oxidase, which was lower livers Vervet monkeys same for 1 year 6 months then returned diet months. dietary manipulations had serum lipid levels aortic sudanophilia. reflected concentration. Six after cessation feeding fat virtually normal. appear exert a do influence sudanophilia vervet monkeys.